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The Roussel Uclaf Causality Assessment Method[54] is a sensitive test but difficult to perform based on its complicated system

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6.1 Optimization of pharmacokinetics and nanocarrier delivery Phytochemicals often face significant pharmacokinetic challenges, such as poor solubility, rapid metabolism, and low bioavailability, which severely limit their clinical application

Preclinical research models indicate that MPs/NPs may accelerate both the initiation and progression of PD by facilitating -synuclein misfolding and aggregation, triggering neuroinflammatory cascades, elevating oxidative stress, and impairing mitochondrial function

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