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Lipolysis and factors regulating the plasma levels of non-esterified fatty acids (NEFAs) also play a role on TRP passage across the BBB, exerting competition for LAT carriers but also promoting, under specific conditions as physical activity, the shift from the albumin-bound TRP to the free form (129, 130)

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b , Volcano plot showing logarithmized fold changes of label-free quantification (LFQ) values in control vs

Dosed directly or mixed with food

10.1113/JP278810 159 VettoreL.WestbrookR

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