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Many angiogenic factors, such as VEGF-A, HGF, transforming growth factor (TGF) and epidermal growth factor (EGF) (Folkman, 2003), demonstrated elevated expression levels in HCC tumors (Mas et al., 2007), Moreover, these factors induce angiogenesis through a number of mechanisms, one of them is via the HGF/c-Met signaling pathway

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With respect to the newness criterion at 419.66(b)(1), FDA granted the applicant 510(k) clearance for the Axoguard HA+ Nerve Protector TM on April 7, 2023, and then granted a second 510(k) clearance for an expanded indication on October 12, 2023

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Update in pathogenesis, diagnosis, and therapy of prolactinoma