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Yet, in other cardiovascular diseases, the connection between inflammation and increased vascular stiffness has been better characterized: here, inflammatory processes have been shown to promote arterial stiffening through a variety of mechanisms, including the induction of endothelial dysfunction and BM stiffening, increased proliferation of SMCs ( In PH, elevated pressure and high pulsatile flow as a consequence of reduced vascular compliance can be sensed by ECs of the pulmonary vascular bed

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