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Okubo T, Tsukimura N, Taniyama T, Ishijima M, Nakhaei K, Rezaei NM, Hirota M, Park W, Akita D, Tateno A, Ishigami T, Ogawa T

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Similarly, CAR T cells engineered to produce proteins that shape local immunity in a beneficial manner, such as IL-12, IL-15, and IL-18 to promote a Th1 response, or a truncated IL-6 receptor to sequester local IL-6, may augment tumoricidal activity without increasing immune-mediated pathology (23, 43)