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It is also a co-factor for GPX4-mediated lipid detoxification 35 , and GPX4 activity is necessary for the survival of several tissues, including the liver 36 and kidney 37

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Loss of polarity in Drosophila wing leads to apoptosis and compensatory proliferation [46]

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Eur J Endocrinol 168:R77R83 Li M, Song L-H, Yue GG-L et al (2017) Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species