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Calcineurin inhibitors, such as tacrolimus and cyclosporine, have remission rates of 6387% in azathioprine-intolerant patients and 4153% in non-responders [111,112,113]

Marine Biology, 47(3), 243250

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Preclinical data highlight 3-5x efficacy gains, although clinical translation requires GSH gradient validation (143) (Figure 3)

A deeper understanding of the mechanisms underlying DCM is essential for identifying novel therapeutic targets

Via screening 18 HDACs for the potential delactylase activity, Zhao and colleagues reported that HDAC1-3 and SIRT1-3 could cleave L-lactyllysine marks in vitro [95], especially for nuclear HDAC1-3 serving as the most robust delactylases, suggesting a critical role of HDAC1-3 for the removal of histone lactylation [95]