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Description

Patients should not attempt to inject themselves unless a healthcare provider has specifically instructed and trained them, and has confirmed that home administration is safe and appropriate

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After that, take a 4-week break before starting again

The desired C2/3-diamino-group may be introduced via a two-step sequence involving an amination of C2-chloro- group with, for example, ammonia and reduction of C3-nitro group (via, e.g., hydrogenation) to give the precursor 16