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Mitochondrial dysfunction has been linked to numerous diseases, including diabetes mellitus, heart disease, cancer, dementia, among others

[Google Scholar] 72.Loguercio C, Piscopo P, Guerriero C, Girolamo VD, Disalvo D, del Vecchio Blanco C

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Distinct tumor necrosis factor alpha receptors dictate stem cell fitness versus lineage output in Dnmt3a-mutant clonal hematopoiesis

Pyruvate is a metabolic product immediately downstream of enolase and has been successfully and safely used in humans as a clinical antioxidant, including as a cardio- and neuro-protectant ( Figure 3C )