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A phase I clinical trial of the anti-CD28 Ab TGN1412 exemplifies this, as the Ab induced cytokine storms in treated individuals, causing severe damage to the lungs and kidneys, and an immediate need of transfer to the intensive care unit [365]

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Furthermore, excessive accumulation of NADH in conjunction with reduced NAD + availability can inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in the glycolytic pathway, leading to glucose shunting to the glycolytic branch pathway (Yan et al., 2016

The published research literature describes mechanism and outcomes in research models

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