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doi: 10.3389/fnagi.2021.776936 Received 14 September 2021 Accepted 30 November 2021 Published 23 December 2021 Volume 13 - 2021 Edited by Magorzata Kujawska, Pozna University of Medical Sciences, Poland Reviewed by Sandra Morais Cardoso, University of Coimbra, Portugal

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Summarizing we provide a detailed characterization of the interaction of p53 with FOXO4 and FOXO4-DRI which is the basis for development of p53 inhibitors to treat diseases linked to cellular senescence such as cancers

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