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If an individual carries two loss-of-function allele variants (i.e., homozygous or heterozygous state) such as two alleles showing deletion (i.e., CYP2D6 *5) or non-functional pattern (i.e., CYP2D6 *4), then a non-functional enzyme or an enzyme with reduced function would be labelled as a poor metabolizer for specific drugs degraded by that enzyme

Whats more, it may be contraindicated for people who are pregnant or wearing medical implants such as pacemakers

(Reference Sekhar, Patel and Guthikonda21) observed that significantly lower concentrations of erythrocyte glutathione in elderly human subjects, compared with younger control subjects, could be re-established by dietary GLY (133 mM/kg/d) and CYS (081 mM/kg/d) supplementation for 14 d

Combined measurement of biomarkers of effect and biomarkers of exposure would provide a more precise diagnosis

Four RCTs of vitamin C in ESA-treated HD patients have been reported (Table 34)

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