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METALLURGY C07ORGANIC CHEMISTRY C07DHETEROCYCLIC COMPOUNDS C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings C07D487/04Ortho-condensed systems CCHEMISTRY

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Moreover, fluxes through 3-hydroxyisobutyryl-CoA hydrolase (3HBCOAHLm) and L-threonine 3-dehydrogenase (THDm) were increased, further supplying more acetyl-CoA via valine and threonine catabolism

One-third of the participants experienced a stable complete response as a result of using cobimetinib and vemurafenib in combination, which has a significant influence on long-term survival [291]

doi: 10.1016/j.bbalip.2014.12.006