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Synergistic action of the nephrotoxic mycotoxins ochratoxin a and citrinin at nanomolar concentrations in human proximal tubule-derived cells

All inflammation, all disease, and everyones complaints are from two things

Abbreviations BPH: Benign prostatic hyperplasia LUTSs: Lower urinary tract symptoms OS: Oxidative stress DEGs: Differentially expressed genes MXRA5: Matrix-remodeling associated 5 CXCL13: C-X-C Motif Chemokine Ligand 13 BMP5: Bone morphogenetic protein 5 NELL2: Neural epidermal growth factor-like like 2 GPX3: Glutathione peroxidase 3 GSH: Glutathione ROS: Reactive oxygen species Cyto-C: Cytochrome c MMP: Mitochondrial membrane potential PCD: Programmed cell death MDA: Malondialdehyde H&E: Hematoxylin and eosin staining IHC: Immunohistochemical DMSO: Dimethyl sulfoxide T: Testosterone propionate RSL3: RAS-selective lethal 3 GPX4: Glutathione peroxidase 4 TRO: Troglitazone PPAR: Peroxisome proliferator-activated receptor Rapa: Rapamycin CQ: Chloroquine Nrf2: Nuclear factor erythroid 2-related factor 2 SOD2: Superoxide dismutase 2

Class I FINs activate ferroptosis by depleting intracellular GSH by inhibiting system X c - [17, 95, 103, 104]

Baur, and J

Hyaluronic Acid Found throughout connective, epithelial (skin) and neural tissues, hyaluronic acid contributes to cell proliferation, differentiation and mitigation