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Mice deficient in thiamine have reduced glutathione levels (hence increased lipid peroxidation) and antioxidant enzymes glutathione peroxidase, SOD, catalase, glutathione reductase and glutathione transferase, as well as increased levels of OS markers, including malondialdehyde

Csukai, M., Chen, C

Nuclei were counterstained with hematoxylin (BBC Biochemical)

How the cell is protected from the damage caused by ERgenerated ROS is poorly understood

In brief, inhibition of TrxR augments the susceptibility of tumor cells to oxidative stress, bolsters the selective eradication of cancerous cells, and instigates the cascade of apoptosis, which has received widespread attention in recent years making TrxR a potential target for cancer therapy (191, 192)

Underwood, 2015