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Effective lipoxygenase inhibitors, such as CDC and zileuton, are free radical-trapping antioxidants (Yang et al., 2016)

AGEs and methylglyoxal induce apoptosis and expression of Mac-1 on neutrophils resulting in platelet-neutrophil aggregation

doi: 10.1038/s41598-020-78003-z 191 MortenKJBadderLKnowlesHJ

In ovarian cancer, tumor-released mesothelin, which is linked to a glycosylphosphatidylinositol (GPI) anchor, binds to MR on macrophages, driving their polarization toward the TAM phenotype, which supports tumor growth and suppresses the immune response

In addition to commonly used iron chelating therapy, regulating hepcidin levels may also help alleviate iron overload in -thalassemia patients, due to their typically low hepcidin levels