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( B ) 2D PCA scores plot demonstrating statistical clustering of WT and 4.2 / RBC metabolomic profiles ( n = 46)

Following treatment, cells were incubated in 10 M of MitoPY1 in PBS for 20 min at 37 C and then collected for analysis

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Nat Commun 8:195

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Other signs may include shortness of breath, pale skin, stomach problems, such as constipation, diarrhea or gas, or nerve problems, like muscle weakness or tingling in fingers or toes. Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says