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doi: 10.1159/000077371 17

Recent studies have also demonstrated that mechanosensitive ion channels, such as Piezo1, can transduce ECM mechanical signals into intracellular chemical signals, thereby affecting gene expression and epigenetic modifications 23,24,25

R.Nbrega-SousaP.et al (2025)

Because oxidative metabolism is mainly performed in mitochondria, the morphology of ferroptosis in cells usually manifests through rupture of the mitochondrial outer membrane, increased membrane density, and loss of ridge contraction

With larger sample sizes, new differentially methylated CpGs are being described beyond interferon-responsive genes

Administering doses higher than natural levels may increase the risk of mortality