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These results suggested that chronic hypoxia promoted the expression of Acer2 by activating HIF-2

10.1016/j.procbio.2012.05.010 Process Biochem

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

Taken together with precedent from oncology, the overall evidence indicates that Erastin has clear therapeutic potential for EMS, provided drug delivery preferentially targets lesions while sparing healthy tissue