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Clozapine and olanzapine also have the greatest potential clinical metabolic liability in that they potently induce weight gain/obesity and increased incidence of type 2 diabetes across the lifespan when compared to other antipsychotic medications (Holt, 2019)

This happens either directly or with help from glutathione S-transferases (GSTs)

When the serum transferrin saturation is about 60%-70%, exceeding the transferrin binding capacity, it forms the NTBI, also known as the unstable iron pool