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References Saurat, J.-H., Halioua, B., Baissac, C., Cullell, N

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels

A slight decrease in activity the day after vaccination is normal, but prolonged lethargy or changes in behavior should prompt a call to your vet

Its short 23 hour half-life means lipolytic effects are transient and must coincide with low insulin (fasted state) and high oxidative demand (exercise) to prevent FFA re-esterification