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Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]

Melatonin inhibits the development of endometriosis by disrupting mitochondrial function and regulating siRNA expression in mouse models (137)

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Flores, H., Lin, S., Contreras-Ferrat, G., Cronan, J

These discrepancies may stem from differences in study design, dosage, duration of supplementation, and baseline nutritional status of participants