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Second, future investigations would benefit from adopting deeply phenotyped, multi-omics longitudinal cohorts that prospectively collect high-resolution metadata on host genetics, diet, and physical activity (Reicher et al., 2025)

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Oral phlorizin treatment counteracted dopamine depletion, alleviated neuroinflammatory responses, and rescued motor deficits in a PD mouse model (Zhang G

Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth

doi: 10.1146/annurev-pharmtox-010818021856 89 PiotrowskaMSwierczynskiMFichnaJPiechota-PolanczykA

We also thank the Biomedical Research Unit and Biomedical Research Core of Tohoku University Hospital and Biomedical Research Core of Tohoku University Graduate School of Medicine for technical support