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*Correspondence: Stephanie Fryar-Williams, [email protected] Specialty section: This article was submitted to Schizophrenia, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cells were treated with 30 nM xCT siRNA (Ambion) for 24 h followed by replacement with serum free DMEM/F12 media for additional 12 h

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A study has suggested that the majority of the subversive effects of O 2 are due to the action of oxygen radicals and an increase in the partial pressure of oxygen or reduction in antioxidant defenses can cause cellular and tissue damage

Therapy with oral folinic acid is effective for treating many aspects of the disorder