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Kheiry M, Dianat M, Badavi M et al (2019) p-coumaric acid attenuates lipopolysaccharide-induced lung inflammation in rats by scavenging ROS production: an in vivo and in vitro study

Neuron 55 , 377391 (2007)

Aside from protecting cells from damage due to excessive oxygen or nitrogen radicals, glutathione plays a number of other key roles, including (1) : Detoxification of toxic compounds Facilitating plasma membrane transport of toxic substances for elimination Scavenging oxygen and nitrogen oxidants Recycling and regenerating other antioxidants (vitamins C and E) Removing heavy metals Regulating cell proliferation and apoptosis Supporting mitochondrial function and maintaining the health of mitochondrial DNA Without sufficient glutathione production or intake, low glutathione status can contribute to the development or worsening of various disease states, some of which include (2, 3) : Premature aging Neurodegenerative disorders (Alzheimers, Parkinsons) Cancer Diabetes HIV/AIDS Autoimmunity Infertility Mental health disorders Its a little nutrient that plays a big role, so supporting it in any way you can is critical to maintaining health and preventing chronic disease development

Dietary interventions further expand this paradigm aged garlic oligosaccharides reshape gut ecology toward Akkermansia -dominant communities with concomitant TMAO reduction in hyperlipidemic ApoE -/- models, whereas hickory polyphenols attenuate atherosclerosis through hepatic FMO3 transcriptional downregulation in high-choline-fed C57BL/6J mice (167, 168)

2023;13:e1465

Exosomes have demonstrated exceptional promise as carriers for chemotherapeutic agents, enabling deeper tumor penetration while reducing systemic toxicity