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Potential limitations include: Limited long-term human data Variable patient response Cost considerations Need for ongoing monitoring Off-label prescribing considerations These therapies are generally avoided in patients with: Active malignancy Pregnancy or breastfeeding Significant uncontrolled endocrine disease Certain metabolic conditions Monitoring and Safety Where prescribed, monitoring may include: IGF-1 levels Functional recovery Sleep quality Rehabilitation tolerance Adverse effects Overall clinical progress Treatment should always be part of a broader recovery plan rather than a standalone intervention

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Henderson 1996)

Biotechnology and Food Science 76:3541 Szymanski M (2014) Molecular mechanisms of lead toxicity

Similarly, chronic (3 years) n-3 PUFA supplementation (0.3 g/day EPA and 0.7 g/day DHA) failed to improve whole-body physical performance when taken alone or in combination with strength training in a cohort of 2,000 healthy men and women aged 70 years and over [104]