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In this process, non-essential energy-consuming mechanisms are reduced, allowing energy molecules to be used for mechanisms that are crucial for viability

This is consistent with previous studies demonstrating that nonsense and frameshift variants in SLC22A5 are typically associated with lower carnitine transport, whereas missense variants may result in proteins with retained residual carnitine transport activity ( PCD has been included in the NBS plan in China based on MS/MS, which is critical for PCD diagnosis and cannot be replaced

[27] The FDA also advises individuals with bipolar disorder, depression, elevated blood pressure, liver or kidney problems, mania, psychosis, Raynaud's phenomenon, seizures, thyroid problems, tics, or Tourette syndrome to monitor their symptoms while taking methamphetamine

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Acknowledgments We thank Figdraw (www.figdraw.com) for figure drawing