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However, the several studies rely on transcriptomic enrichment analyses or pharmacological intervention models, and the temporal relationship between ferroptosis activation and muscle fiber loss remains incompletely defined (92-94)

With an unpaired electron, NO, which is a highly reactive free radical, damages proteins, carbohydrates, nucleotides and lipids and, together with other inflammatory mediators, results in cell and tissue damage, low-grade, sterile inflammation and adhesions [20]

Eur Arch Paediatr Dent 26 , 169181 (2025)

In contrast, several studies reported that APR-246s activity is independent of p53 status, whether WT, null, or missense mutated [41,42,43,44,45]

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Several points of synergy amplify the combined effect