low total glutathione Oxidative Stress Levels in the

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Therefore, sphingolipid-autophagy crosstalk constitutes a pivotal regulatory nexus governing Treg stability, whose diabetic disruption propagates T1DM immunopathology by crippling immunosuppressive circuits, while pharmacologically restoring this axis emerges as a strategic therapeutic paradigm for re-establishing immune tolerance (Figure 5)

Annu Rev Pharm Toxicol

Rights and permissions About this article Cite this article Mok, E., Constantin, B., Favreau, F

We are grateful to Dr Ravi Manjithaya, JNCASR, Bengaluru for his suggestions regarding the high throughput screens and assays

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