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Barbanti P, Aurilia C, Egeo G, et al

Pharmacokinetics: administered as eye drops, or topically to the skin does not readily cross the blood brain barrier due to a low lipid solubility

These -subunits connect with the appropriate effectors to provide downstream effects, such as ion channel opening or modulation of enzyme activity

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The combination of COX-1 & (at higher doses) COX-2 inhibition are the molecular basis for aspirin's analgesic, antipyretic & anti-inflammatory effects