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One-time therapies with potentially millions of dollars of future value to patients carry seven-figure price tags, reflecting the current drug paradigm of paying drug companies up front when the drug is administered.[4] As a result, high costs have often presented the primary barrier to access, ahead even of the risks and complexities of treatment.[5] The diffusion of CGTs has lagged behind expectations, even for subpopulations that might realize life-changing benefits, such as people with sickle cell disease (SCD).[6] Medicaid programs face constraints in their ability to finance large outlays for even a small number of qualifying patients.[7, 8] Meanwhile, among commercial insurers, traditional stop-loss insurance mechanisms have proven insufficient to address the challenge

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Beyond that, desensitization is inevitable

Pharmacokinetic stability research in serum-containing buffer systems, examining the resistance of N-terminally modified GHRH analogs to dipeptidyl peptidase-IV (DPP-IV) and other proteases

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