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Many freshwater species of decapod crustaceans have a V-ATPase that is localized to the apical membrane of their osmoregulatory gill epithelia (e.g., Dilocarcinus pagei and a number of grapsid crabs: Eriocheir sinensis, Hemigrapsus sanguineus , and Perisesarma bidens ) (Onken and Putzenlechner, 1995

upon binding to TGF1, it recruits TGFBR1 and induces its phosphorylation, thereby activating downstream canonical (SMAD-dependent) and non-canonical (non-SMAD-dependent) intracellular signaling cascades

NRF2 has a dual function, whereby reducing its expression can enhance the susceptibility to cancer cells to iron-death, while raising NRF2 levels can impede the ferroptosis process [15, 60]