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It supports the protection and regeneration of the digestive lining, aiding recovery from damage caused by ulcers, inflammation, or injury

doi: 10.3389/fmicb.2026.1795711 Received 25 January 2026 Revised 06 March 2026 Accepted 26 March 2026 Published 23 April 2026 Volume 17 - 2026 Edited by Annalisa Ciabattini, University of Siena, Italy Reviewed by Jian Xu, Kyushu University, Japan Giuditta Guerrini, Joint Research Center, Italy Updates Copyright 2026 Liu, Zhang, Liang, Zhang, Zhang, Rong, Tan and Mi

It occurs in a variety of forms most of which are active within the body

The activation promotes angiogenesis and improves blood flow to damaged, hypovascular tissues (tendons and ligaments)

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In this sense, PACAP has been postulated as the GHRH ancestor in less evolved vertebrates (50, 170, 173)