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Nonetheless, extant clinical trials and vast research in animal models indicate a positive safety profile [17]

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Mutation of the SAM-keyprotrusion I interaction surface in Fun30 phenocopied the SAM-key domain deletion, suggesting that allosteric activation of the remodeler by the SAM-key domain is required for Fun30 enzymatic activity

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THP-1 cells were seeded at 1 10 5 cells per well and differentiated as described above