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Iron is not recommended for RLS patients with ferritin levels higher than 300 ng/mL or transferrin saturation higher than 45% (Winkelman 2026)

(2018) 6:e1000257

In addition, the N-terminal thioredoxin-like domain of GST, known as the G-site, is responsible for GSH binding 22

These compounds also break down and digest faster

Mechanistically, AUR disrupts redox-homeostasis by irreversibly binding to the selenocysteine active site of intracellular TrxR, thereby inhibiting Trx reduction and impairing ROS detoxification [38]