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[DOI] [PubMed] [Google Scholar] 58.Podolsky A.T., Sandweiss A., Hu J., Bilsky E.J., Cain J.P., Kumirov V.K., Lee Y.S., Hruby V.J., Vardanyan R.S., Vanderah T.W

455 A subsequent phase 2 (NCT04857996) study evaluated the activity of a single intravitreal injection of UBX1325 for the treatment of DME

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Increases in H 2 S levels could also potentially lead to the persulfidation (sulfhydration) and activation of enzymes such as glycerol-3-phosphate dehydrogenase 1 (GPD1) or glycerol-3-phosphate dehydrogenase 2 (GPD2) that comprise the glycerol-3-phosphate shuttle (G3PS) to increase cytoplasmic NADH redox shuttling (Petrovic et al., 2025)