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There have been concerns that having the MTHFR variation or elevated homocysteine levels could potentially interfere with future insurance coverage, that may limit pre-existing conditions

doi: 10.1016/j.cell.2023.05.001 247 SchneiderAHuberLLohseJLindeKGreisselASattelHet al

WaterhouseMHopeBKrauseLMorrisonMProtaniMMZakrzewskiMet al

Hagag AA, Elgamsy MA, El-Asy HM, Mabrouk MM (2016) Protective role of silymarin on hepatic and renal toxicity induced by MTX based chemotherapy in children with acute lymphoblastic leukemia

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In agreement with these observations, NAC failed to shorten the lifespan of WDR-23-deficient animals (Supplementary Fig