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Int J Dev Neurosci 27:599605 Khedr LH, Rahmo RM, Eldemerdash OM, Helmy EM, Ramzy FA, Lotfy GH, Zakaria HA, Gad MM, Youhanna MM, Samaan MH (2024) Implication of M2 macrophage on NLRP3 inflammasome signaling in mediating the neuroprotective effect of Canagliflozin against methotrexate-induced cognitive impairment