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Because IDO1 -associated inflammatory activation would be expected to increase, rather than decrease, the Kyn/Trp ratio [46,47,48], a one-tailed analysis was also performed

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Flueraru M, Chichirau A, Chepelev LL, Willmore WG, Durst T, Charron M, Barclay LRC, Wright JS (2005) Cytotoxicity and cytoprotective activity in naphthalenediols depends on their tendency to form naphthoquinones