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It should be noted that while ingested curcumin is cleared rapidly, which is considered disadvantageous, however the amount of administered curcumin (3600 mg daily) conferred sufficient anti-oxidant activity in human intestinal tract to result in pharmacodynamic changes corresponding to intestinal chemopreventions [414, 415]

DomeneghiniCDi GiancamilloABosiGArrighiS

Nevertheless, the limited targeting capacity of conventional drugs results in suboptimal drug concentrations at sites of active intestinal inflammation, thereby restricting therapeutic effectiveness

Funding This research was supported by the Arkansas Biosciences Institute (Little Rock, AR, USA), The Jonty Foundation (St Paul, MN), The Autism Research Institute (San Diego, CA), the Gupta Family Foundation (Atherton, CA), The Jane Bostford Johnson Foundation (New York, NY) and the Jager Family Foundation (Chicago, IL)

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