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A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

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Vitamin B12 deficiency results in severe oxidative stress, leading to memory retention impairment in Caenorhabditis elegans

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The total of four conversions of NAD + to NADH in the joint glutamate synthesis/oxidation process suggested [two in astrocytes during the production of -ketoglutarate and one during glutamate oxidation (Figure 3B), together with one in neurons (Figure 5)] may explain the close to 1:1 ratio between rates of glucose oxidation and of glutamine/glutamate (GABA) cycle flux