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doi: 10.1155/2022/6324462 87 National Institute on Drug Abuse

Over the years, low HDL-C levels have consistently been reported to be associated with increased risk of ASCVD and events (716-718)

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By week eight the mirror started telling a different story

At a glance Interaction type / pharmacokinetic (CYP3A4 inhibition) plus pharmacodynamic (additive BP lowering) Enzyme involved / CYP3A4 (primary route of amlodipine metabolism) Resveratrol dose linked to CYP inhibition / as low as 500 mg/day in human PK studies Amlodipine half-life / 30 to 50 hours, so enzyme inhibition effects accumulate slowly Main clinical risk / symptomatic hypotension, reflex tachycardia, worsened pedal edema Estrogenic concern / resveratrol binds estrogen receptor alpha

This interaction leads to both inhibition of T cell proliferation and B cell antibody production (70, 71)