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Zinc- 2-glycoprotein (ZAG), a novel adipokine, was shown to be inhibited by a high-fat diet and obesity, inflammatory stimuli (TNF ), glucocorticoid receptor antagonists, eicosapentaenoic acid, and 3-adrenoceptor antagonists, whereas glucocorticoids, cancer cachexia, and 3-agonists increase ZAG production [88]

doi: 10.3389/fphar.2019.00573 88 WanXGenFShengYOuMWangFPengTet al

Intracellular Cu targets and binds to lipoylated components in the tricarboxylic acid (TCA) cycle, and aggregation of these Cu-bound lipoylated mitochondrial proteinsand the subsequent reduction in FeS (ironsulfur) clustersinduces proteotoxic stress and ultimately cell death

This sparked our interest in using wine grape-derived products in beer to pack even more precursor thiols into the wort

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