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However, KEAP1 is not only a factor involved in regulating NRF2 inhibition and turnover, but it may also be a sensor of oxidative stimuli

[13] In the setting of acute isoniazid overdose or toxicity, extraordinarily high doses of pyridoxine are used as an antidote: the recommended approach is to administer pyridoxine in a total amount equal to the amount of isoniazid ingested