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These protective effects are attributed to resveratrol's pleiotropic mechanisms of action, which include its potent antioxidant capacity, suppression of proinflammatory signaling pathways such as NFB, and activation of sirtuin1 (SIRT1) a longevityassociated deacetylase implicated in neuronal survival and metabolic regulation

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It's less common as an oral supplement in the US

ANGPTL4: angiopoietin-like 4 gene