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Although targeting oxidative stress is theoretically logical, most strategies currently employed in the clinical setting have failed to improve patient prognosis

These findings were observed in our analysis of four independent large clinical datasets, and the hypothesis was further validated via in vivo and in vitro studies on rats

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Although intraocular bimatoprost achieved a target duration of 34 months, the efficacy of the implant was not observed over a much longer period [78, 79]