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Relevant roles of each specific IGFBPs will be further discussed when applicable to metabolism since there is a huge emerging world of IGFBPs independent actions

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Cell culture applications utilize concentrations of 10-50 M for effective senescent cell elimination, with administration durations typically 24-72 hours depending on experimental objectives and cellular models

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[17] Knockout studies with GPX1, GPX2, or GPX3 deficient mice showed that cytosolic GPX4 is so far the only glutathione peroxidase that is indispensable for embryonic development and cell survival