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In preclinical mouse models, we and others showed that increased hepatic ammonia due to the loss of GLUL or increased ammonia import via SLC4A11 can promote HCC development ( 7 , 8 )

DHODH is a flavoprotein of the electron transport chain that is anchored to the inner mitochondrial membrane, where it performs its canonical function in de novo pyrimidine synthesis (37)

10.1016/j.canlet.2013.11.011 61

A recent case series found reasonable outcomes, but long-term data and FDA approval specifically for this level remain uncertain

Cancer 10 , 147156 (2010)

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