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Because metabolite-receptor interactions are often highly stereospecific 53,54 , we developed a synthesis employing Sharpless chiral resolution and subsequent chirality transfer via Claisen rearrangement to access the two enantiomers of bemeth#1, (3 R) -bemeth#1 and (3 S) -bemeth#1 (Fig

DOX + (SP + L-car) group Prior to starting chemotherapy, the rats were given SP (500 mg/kg

HS exhibits a biphasic effect in cancer biology: at low concentrations, it enhances mitochondrial function and promotes glycolysis, thereby supporting cancer cell proliferation, whereas at high concentrations, it inhibits proliferation