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Acknowledgements The authors are thankful for the assistance with patch-clamp and plate reader investigations from the technicians Fatih and Muhammet ahin (BSN Health)

The M9 was aspirated from the tube and replaced with 1mL fresh M9 and spun again

Endothelial dysfunction is linked to the pathophysiology of CVDs (57)

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The injection site is typically chosen based on muscle size and accessibility, with common sites including the deltoid (shoulder), gluteus (buttocks), and vastus lateralis (thigh)